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KMID : 0620920020340010053
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Experimental & Molecular Medicine
2002 Volume.34 No. 1 p.53 ~ p.59
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Enhanced expression of neuronal nitric oxide synthase and phospholipase C-γ1 in regenerating murine neuronal cells by pulsed electromagnetic field
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Sung Min Chung/Sung Sook Kim
Hye Jung Shin*/Dae Woon Eom/Joo Ryung Huh/Yeong Ju Woo/Hyo Kyung Kim†/Sung Ho Ryu‡/Pann Gill Suh‡/Moon Jung Kim*/Jee Yun Kim*/Tae Wan Koo*/Yoon Hee Cho*/Sung Min Chung*
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Abstract
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Pulsed electromagnetic field (PEMF) has been shown to improve the rate of peripheral nerve regeneration. In the present study we investigated the expression of neuronal nitric oxide synthase (nNOS) and phospholipase C-γ1 (PLC-γ1) in regenerating rat laryngeal nerves during the exposure to PEMF after surgical transection and reanastomosis. Axons were found to regenerate into the distal stump nearly twice faster in PEMF-exposed animals than in the control. Consistently, motor function was better recovered in PEMF-treated rats. The expression of nNOS and PLC-γ1 was highly enhanced in the regenerated nerves.
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KEYWORD
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PEMF, PLC-γ1, NOS, S-100,
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